Tert-butyl 1,3-dioxoisoindolin-2-ylcarbamate

Base Information

Chemical Name:Tert-butyl 1,3-dioxoisoindolin-2-ylcarbamate
CAS No.:34387-89-8
Molecular Formula:C13H14 N2 O4
Molecular Weight:262.265
Hs Code.:2925190090
European Community (EC) Number:838-781-2
DSSTox Substance ID:DTXSID10355437
Nikkaji Number:J1.383.950F
Wikidata:Q82134341
Mol file:34387-89-8.mol

Synonyms:34387-89-8;TERT-BUTYL 1,3-DIOXOISOINDOLIN-2-YLCARBAMATE;N-(Boc-amino)phthalimide;N-(tert-Butoxycarbonylamino)phthalimide;tert-butyl N-(1,3-dioxoisoindol-2-yl)carbamate;N-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)(tert-butoxy)formamide;MFCD00686624;SCHEMBL1407285;DTXSID10355437;IOPZBVFVFPPDSC-UHFFFAOYSA-N;HMS1585G15;CS-M1023;(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-carbamic acid tert-butyl ester;AKOS000612403;N-tert-butyloxycarbonylaminophthalimide;SB64089;AS-19801;SY123417;FT-0685034;t-butyl (1,3-dioxoisoindolin-2-yl)carbamate;EN300-180479;W10661;tert-Butyl N-(1,3-dioxoisoindolin-2-yl)carbamate;J-019581;J-524386;tert-Butyl 1,3-dioxoisoindolin-2-ylcarbamate, 95%;tert-butyl (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)carbamate;tert-butyl 1,3-dioxo-1,3-dihydro-2H-isoindol-2-ylcarbamate;N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-carbamic acid 1,1-dimethylethyl ester

Suppliers and Price of Tert-butyl 1,3-dioxoisoindolin-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(tert-Butoxycarbonylamino)phthalimide
2.5g
$ 160.00

Crysdot
N-(tert-Butoxycarbonylamino)phthalimide 95+%
1g
$ 150.00

Crysdot
N-(tert-Butoxycarbonylamino)phthalimide 95+%
5g
$ 450.00

Chemenu
N-(tert-Butoxycarbonylamino)phthalimide 95%
5g
$ 421.00

Atlantic Research Chemicals
N-(BOC-AMINO)PHTHALIMIDE 95%
1gm:
$ 134.31

Ambeed
N-(tert-Butoxycarbonylamino)phthalimide 95%
5g
$ 58.00

Ambeed
N-(tert-Butoxycarbonylamino)phthalimide 95%
1g
$ 18.00

Ambeed
N-(tert-Butoxycarbonylamino)phthalimide 95%
25g
$ 205.00

Alichem
N-(tert-Butoxycarbonylamino)phthalimide
5g
$ 477.00

Alichem
N-(tert-Butoxycarbonylamino)phthalimide
1g
$ 150.00

Total 37 raw suppliers

Chemical Property of Tert-butyl 1,3-dioxoisoindolin-2-ylcarbamate

Chemical Property:

Melting Point:140-145 °C
PKA:7.46±0.20(Predicted)
PSA：66.48000
Density:1.32±0.1 g/cm3(Predicted)
LogP:1.68870
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:tetrahydrofuran: 50 mg/mL, clear, colorless
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:262.09535693
Heavy Atom Count:19
Complexity:389

Purity/Quality:

99%, ^*data from raw suppliers

N-(tert-Butoxycarbonylamino)phthalimide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NN1C(=O)C2=CC=CC=C2C1=O

Technology Process of Tert-butyl 1,3-dioxoisoindolin-2-ylcarbamate

There total 2 articles about Tert-butyl 1,3-dioxoisoindolin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 85-44-9
phthalic anhydride

: 870-46-2
t-butoxycarbonylhydrazine

: 34387-89-8
N-(tert-butoxycarbonylamino)phthalimide

Guidance literature:: In toluene; for 3h; Heating;
DOI:10.1002/ejoc.200300445

Reference yield:

: 85-44-9
phthalic anhydride

: 34387-89-8
N-(tert-butoxycarbonylamino)phthalimide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / tetrahydrofuran / 0.08 h / 20 °C

2: 82 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1 h

3: acetic acid; triethylamine / tetrahydrofuran / 1 h / Heating

With acetic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1: Acylation / 2: Cyclization / 3: Isomerization;
DOI:10.1021/jo000225s

Reference yield: 96.0%

: 34387-89-8
N-(tert-butoxycarbonylamino)phthalimide

: 100-39-0
benzyl bromide

: 287729-00-4
N-benzyl-N-tert-butyloxycarbonylaminophthalimide

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetonitrile; at 50 ℃; for 2h;
DOI:10.1002/ejoc.200300445