3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

Chemical Name:3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:177906-31-9
Molecular Formula:C₁₈H₂₁N₅O₆
Molecular Weight:403.395
Hs Code.:

Synonyms:3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of 3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of 3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 3 articles about 3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 177906-30-8
3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid

: 177906-31-9
3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In ethyl acetate; acetone; at 0 ℃; for 12h;
DOI:10.1248/cpb.44.972

Reference yield:

: 10494-79-8
methyl N-(3-hydroxypropyl)-β-alaninate

: 177906-31-9
3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaHCO₃ / dimethylsulfoxide; ethyl acetate / Ambient temperature

2: pyridine / CH₂Cl₂ / 4 h / 0 °C

3: NaN₃ / dimethylformamide / 48 h / Ambient temperature

4: 99 percent / 1.0 N NaOH / methanol / 1.5 h / 60 °C

5: DCC / acetone; ethyl acetate / 12 h / 0 °C

With pyridine; sodium hydroxide; sodium azide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.45.93

Reference yield:

: 177906-28-4
3-[Benzyloxycarbonyl-(3-methanesulfonyloxy-propyl)-amino]-propionic acid methyl ester

: 177906-31-9
3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaN₃ / dimethylformamide / 48 h / Ambient temperature

2: 99 percent / 1.0 N NaOH / methanol / 1.5 h / 60 °C

3: DCC / acetone; ethyl acetate / 12 h / 0 °C

With sodium hydroxide; sodium azide; dicyclohexyl-carbodiimide; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.45.93