(3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Base Information

Chemical Name:(3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester
CAS No.:177906-37-5
Molecular Formula:C₄₅H₅₄N₈O₈
Molecular Weight:834.973
Hs Code.:

(3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Synonyms:(3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

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Chemical Property of (3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

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Technology Process of (3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

There total 15 articles about (3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 113978-98-6
dibenzyl-2,4-dihydroxyphenylacetic acid N-hydroxysuccinimide ester

: 177906-34-2
{2-[5-((S)-2-Amino-3-carbamoyl-propionylamino)-pentylcarbamoyl]-ethyl}-(3-azido-propyl)-carbamic acid benzyl ester

: 177906-37-5
(3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1248/cpb.44.972

Reference yield:

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 177906-37-5
(3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 81.7 percent / K₂CO₃ / acetone / 40 h / Ambient temperature

2: 95.6 percent / TTN, 70percent HClO₄ / 1.33 h / Ambient temperature

3: 99 percent / aq. LiOH / methanol; dimethylformamide / Ambient temperature

4: 80 percent / DCC / acetone; ethyl acetate / a) 0 deg C, 3 h, b) RT, overnight

5: 90 percent / Et₃N / dimethylformamide / 12 h / Ambient temperature

With lithium hydroxide; perchloric acid; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; thallium(III) nitrate; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.44.972

Reference yield:

: 22877-01-6
2,4-bis(benzyloxy)acetophenone

: 177906-37-5
(3-Azido-propyl)-[2-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95.6 percent / TTN, 70percent HClO₄ / 1.33 h / Ambient temperature

2: 99 percent / aq. LiOH / methanol; dimethylformamide / Ambient temperature

3: 80 percent / DCC / acetone; ethyl acetate / a) 0 deg C, 3 h, b) RT, overnight

4: 90 percent / Et₃N / dimethylformamide / 12 h / Ambient temperature

With lithium hydroxide; perchloric acid; triethylamine; dicyclohexyl-carbodiimide; thallium(III) nitrate; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.44.972