3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal

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Chemical Name:3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal
CAS No.:205490-30-8
Molecular Formula:C₆₅H₉₃NO₁₃Si₂
Molecular Weight:1152.62
Hs Code.:

3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal

Synonyms:3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal

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Chemical Property of 3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal

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Technology Process of 3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal

There total 6 articles about 3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 172213-23-9
(3R,4S)-1-benzoyl-3-triisopropylsilyloxy-4-phenylazetidin-2-one

: 205490-29-5
7,9,10,13-tetradeacetyl-10-triethylsilylbaccatin VI 7,9-benzylidene acetal

: 205490-30-8
3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;
DOI:10.1021/jo981406l

Reference yield:

: 994-30-9
triethylsilyl chloride

: 205490-30-8
3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / imidazole / dimethylformamide / Ambient temperature

2: 37 percent / MeLi / tetrahydrofuran; diethyl ether / 0.25 h / -78 °C

3: 69 percent / NaH / tetrahydrofuran / 2.5 h / 0 - 20 °C

With 1H-imidazole; methyllithium; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo981406l

Reference yield:

: 100-52-7
benzaldehyde

: 205490-30-8
3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / CSA, 4 Angstroems MS / toluene / 15 h / 40 °C

2: 72 percent / imidazole / dimethylformamide / Ambient temperature

3: 37 percent / MeLi / tetrahydrofuran; diethyl ether / 0.25 h / -78 °C

4: 69 percent / NaH / tetrahydrofuran / 2.5 h / 0 - 20 °C

With 1H-imidazole; 4 Angstroems MS; camphor-10-sulfonic acid; methyllithium; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo981406l