7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one

Base Information

Chemical Name:7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one
CAS No.:221123-57-5
Molecular Formula:C₂₃H₂₈FNO₅
Molecular Weight:417.477
Hs Code.:

Synonyms:7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one

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Chemical Property of 7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one

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Technology Process of 7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one

There total 9 articles about 7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 221123-56-4
2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

: 221123-57-5
7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one

Guidance literature:: With lithium chloride; In water; dimethyl sulfoxide; at 160 ℃; for 24h;
DOI:10.1021/jo981844s

Reference yield:

: 15017-52-4
4-(bromomethyl)-1-fluoro-2-nitrobenzene

: 221123-57-5
7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / dimethylformamide / 0.67 h / 0 °C

1.2: 73 percent / dimethylformamide / 0.5 h / 0 °C

2.1: 100 percent / aq. HCl / Heating

3.1: 84 percent / BH₃*THF / tetrahydrofuran / 2 h / Heating

4.1: pyridine / Heating

5.1: 1.10 g / NaI / acetone / 48 h / 20 °C

6.1: 86 percent / K₂CO₃; Cs₂CO₃ / acetonitrile / 24 h / Heating

7.1: 83 percent / LiCl / dimethylsulfoxide; H₂O / 24 h / 160 °C

With pyridine; hydrogenchloride; borane-THF; sodium hydride; potassium carbonate; caesium carbonate; sodium iodide; lithium chloride; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; 1.1: Metallation / 1.2: Alkylation / 2.1: Decarboxylation / 3.1: Reduction / 4.1: Tosylation / 5.1: Substitution / 6.1: Alkylation / 7.1: Krapcho decarboxylation;
DOI:10.1021/jo981844s

Reference yield:

: 160877-40-7
3-(4-fluoro-3-nitrophenyl)propionic acid

: 221123-57-5
7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / BH₃*THF / tetrahydrofuran / 2 h / Heating

2: pyridine / Heating

3: 1.10 g / NaI / acetone / 48 h / 20 °C

4: 86 percent / K₂CO₃; Cs₂CO₃ / acetonitrile / 24 h / Heating

5: 83 percent / LiCl / dimethylsulfoxide; H₂O / 24 h / 160 °C

With pyridine; borane-THF; potassium carbonate; caesium carbonate; sodium iodide; lithium chloride; In tetrahydrofuran; water; dimethyl sulfoxide; acetone; acetonitrile; 1: Reduction / 2: Tosylation / 3: Substitution / 4: Alkylation / 5: Krapcho decarboxylation;
DOI:10.1021/jo981844s