2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

Base Information

Chemical Name:2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester
CAS No.:221123-56-4
Molecular Formula:C₂₆H₃₂FNO₇
Molecular Weight:489.541
Hs Code.:

Synonyms:2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

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Chemical Property of 2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

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Technology Process of 2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

There total 8 articles about 2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 221123-67-7
3-(4-fluoro-3-nitrophenyl)propyl iodide

: 221123-54-2
5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

: 221123-56-4
2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

Guidance literature:: With potassium carbonate; caesium carbonate; In acetonitrile; for 24h; Heating;
DOI:10.1021/jo981844s

Reference yield:

: 15017-52-4
4-(bromomethyl)-1-fluoro-2-nitrobenzene

: 221123-56-4
2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 0.67 h / 0 °C

1.2: 73 percent / dimethylformamide / 0.5 h / 0 °C

2.1: 100 percent / aq. HCl / Heating

3.1: 84 percent / BH₃*THF / tetrahydrofuran / 2 h / Heating

4.1: pyridine / Heating

5.1: 1.10 g / NaI / acetone / 48 h / 20 °C

6.1: 86 percent / K₂CO₃; Cs₂CO₃ / acetonitrile / 24 h / Heating

With pyridine; hydrogenchloride; borane-THF; sodium hydride; potassium carbonate; caesium carbonate; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; acetonitrile; 1.1: Metallation / 1.2: Alkylation / 2.1: Decarboxylation / 3.1: Reduction / 4.1: Tosylation / 5.1: Substitution / 6.1: Alkylation;
DOI:10.1021/jo981844s

Reference yield:

: 160877-40-7
3-(4-fluoro-3-nitrophenyl)propionic acid

: 221123-56-4
2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / BH₃*THF / tetrahydrofuran / 2 h / Heating

2: pyridine / Heating

3: 1.10 g / NaI / acetone / 48 h / 20 °C

4: 86 percent / K₂CO₃; Cs₂CO₃ / acetonitrile / 24 h / Heating

With pyridine; borane-THF; potassium carbonate; caesium carbonate; sodium iodide; In tetrahydrofuran; acetone; acetonitrile; 1: Reduction / 2: Tosylation / 3: Substitution / 4: Alkylation;
DOI:10.1021/jo981844s