[2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester
CAS No.:844856-98-0
Molecular Formula:C₃₇H₄₇NO₇
Molecular Weight:617.783
Hs Code.:

Synonyms:[2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

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Chemical Property of [2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

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Technology Process of [2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

There total 5 articles about [2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 100-39-0
benzyl bromide

: 844856-96-8
[2-hydroxy-2-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

: 844856-98-0
[2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.25h; Cooling with ice;
DOI:10.1021/ol301331t

Reference yield: 71.0%

: 100-39-0
benzyl bromide

: 844856-96-8
[2-hydroxy-2-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

: (4S,5S)-3-Benzyl-5-((7S,8S)-8-benzyloxy-1,4-dioxa-spiro[4.5]dec-7-yl)-4-(4-methoxy-benzyl)-oxazolidin-2-one

: 844856-98-0
[2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; silver(l) oxide; at 20 ℃; for 12h;
DOI:10.1021/jo0483567

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 844856-98-0
[2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: iPr₂NH; n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: ZnCl₂ / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.3: 56 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.1: 71 percent / Bu₄NI; Ag₂O / 12 h / 20 °C

With n-butyllithium; tetra-(n-butyl)ammonium iodide; diisopropylamine; silver(l) oxide; In tetrahydrofuran; hexane; 2.1: Luche reduction;
DOI:10.1021/jo0483567