4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid

Base Information

• Chemical Name: 4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid
• CAS No.: 74448-36-5
• Molecular Formula: C₁₁H₉Cl₂NO₃
• Molecular Weight: 274.103
• Mol file: 74448-36-5.mol

Synonyms:4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid

Chemical Property of 4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid

There total 2 articles about 4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.4%

→ Methyl N-(3,4-dichlorophenyl)-2-methylenesuccinamate (80576-65-4) + 4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid (74448-36-5)

Guidance literature:

Reference yield:

itaconic acid anhydride (2170-03-8) + m,p-dichloroaniline (95-76-1) → 4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid (74448-36-5)

Guidance literature:

In chloroform; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.0c00584

Reference yield: 99.0%

4-[(3,4-dichlorophenyl)amino]2-methylidene 4-oxo butanoic acid (74448-36-5) + tiolacetic acid (507-09-5) → 2-((acetylthio)methyl)-4-((3,4-dichlorophenyl)amino)-4-oxobutanoic acid

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/acs.jmedchem.0c00584

upstream raw materials:

itaconic acid anhydride

m,p-dichloroaniline

Downstream raw materials:

1-(3,4-dichlorophenyl)-3-methylenepyrrolidine-2,5-dione