4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine

Base Information

• Chemical Name: 4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine
• CAS No.: 1356140-66-3
• Molecular Formula: C₃₂H₃₂ClN₃O₇
• Molecular Weight: 606.075
• Mol file: 1356140-66-3.mol

Synonyms:4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine

Chemical Property of 4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine

There total 3 articles about 4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2′-deoxycytidine (32387-56-7) → 4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine (1356140-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 9 h / 45 °C

2: pyridine / 5 h / 20 °C

With pyridine; In N,N-dimethyl-formamide;

DOI:10.1039/c1ob06411h

Reference yield:

2'-Deoxycytidine (951-77-9) → 4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine (1356140-66-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-chloro-succinimide; acetic acid / 0.33 h / 95 °C

2: N,N-dimethyl-formamide / 9 h / 45 °C

3: pyridine / 5 h / 20 °C

With pyridine; N-chloro-succinimide; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1039/c1ob06411h

Reference yield:

C11H14ClN3O5 + 4,4'-dimethoxytrityl chloride (40615-36-9) → 4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine (1356140-66-3)

Guidance literature:

With pyridine; at 20 ℃; for 5h;

DOI:10.1039/c1ob06411h

upstream raw materials:

4,4'-dimethoxytrityl chloride

5-chloro-2′-deoxycytidine

2'-Deoxycytidine

Downstream raw materials:

4-N-acetyl-5-chloro-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)