3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester

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Chemical Name:3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester
CAS No.:220046-05-9
Molecular Formula:C₂₃H₂₄ClNO₈
Molecular Weight:477.898
Hs Code.:

Synonyms:3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester

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Chemical Property of 3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester

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Technology Process of 3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester

There total 6 articles about 3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 208193-04-8
3-Chloro-benzoic acid (1R,2R,3R)-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-6-oxo-cyclohexyl ester

: 3-Chloro-benzoic acid (1R,2R,3R,6R)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester

: 220046-05-9
3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.25h;
DOI:10.1016/S0040-4020(98)00975-2

Reference yield:

: 937-14-4
3-chloro-benzenecarboperoxoic acid

: 220046-05-9
3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / CH₂Cl₂ / 0.25 h / 0 °C

2: 88 percent / aq. HCl / ethanol / 1 h / 90 °C

3: 72 percent / NaBH₄ / methanol / 0.25 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(98)00975-2

Reference yield:

: (R)-6-(7-Methoxy-benzo[1,3]dioxol-5-yl)-3-triisopropylsilanyloxy-cyclohex-2-enylamine

: 220046-05-9
3-Chloro-benzoic acid (1R,2R,3R,6S)-6-hydroxy-3-(7-methoxy-benzo[1,3]dioxol-5-yl)-2-methoxycarbonylamino-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / pyridine; CH₂Cl₂ / 1.5 h / 0 °C

2: 83 percent / CH₂Cl₂ / 0.25 h / 0 °C

3: 88 percent / aq. HCl / ethanol / 1 h / 90 °C

4: 72 percent / NaBH₄ / methanol / 0.25 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; In pyridine; methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(98)00975-2