cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester

Base Information

• Chemical Name: cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester
• CAS No.: 1044871-64-8
• Molecular Formula: C₂₇H₃₃N₃O₆
• Molecular Weight: 495.576
• Mol file: 1044871-64-8.mol

Synonyms:cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester

Chemical Property of cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester

There total 10 articles about cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

hydrochloride of 4-(6,8-dimethoxyisoquinolin-3-yl)-2,6-dimethylphenol (1044870-37-2) + Cyclohexyl isocyanate (3173-53-3) → cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester (1044871-64-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 4h; Heating / reflux;

Reference yield: 73.0%

2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one (1044870-39-4) + Cyclohexyl isocyanate (3173-53-3) → cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester (1044871-64-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 4h; Heating / reflux;

Reference yield:

2-amino-4,6-dimethoxybenzoic acid (21577-57-1) → cyclohexylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester (1044871-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 3 h / 20 °C

1.2: 16 h / 20 °C

2.1: toluene-4-sulfonic acid; sodium hydrogensulfite / ISOPROPYLAMIDE / 14 h / 150 °C

3.1: triethylamine / tetrahydrofuran / 4 h / Heating / reflux

With 4-methyl-morpholine; benzotriazol-1-ol; toluene-4-sulfonic acid; sodium hydrogensulfite; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; ISOPROPYLAMIDE;

upstream raw materials:

hydrochloride of 4-(6,8-dimethoxyisoquinolin-3-yl)-2,6-dimethylphenol

Cyclohexyl isocyanate

2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one

4,6-dimethoxyindoline-2,3-dione