4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide

Base Information

Chemical Name:4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide
CAS No.:1456928-88-3
Molecular Formula:C₂₅H₁₉N₃O₂S
Molecular Weight:425.511
Hs Code.:

Synonyms:4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide

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Chemical Property of 4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide

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Technology Process of 4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide

There total 7 articles about 4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: C₃₀H₂₇N₃O₃S

: 1456928-88-3
4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide

Guidance literature:: With hydrogenchloride; In methanol; at 0 ℃; for 1h;
DOI:10.2174/1570180811310070010

Reference yield:

: 1456928-95-2
4-(5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl) phenol

: 1456928-88-3
4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2.1: lithium hydroxide; methanol / water / 4 h / 30 °C

3.1: HATU / N,N-dimethyl-formamide / 0.25 h / 25 °C / Inert atmosphere

3.2: 14 h

4.1: hydrogenchloride / methanol / 1 h / 0 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; HATU; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.2174/1570180811310070010

Reference yield:

: 1456928-97-4
4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoic acid

: 1456928-88-3
4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)-N-(4-methylthiophen-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HATU / N,N-dimethyl-formamide / 0.25 h / 25 °C / Inert atmosphere

1.2: 14 h

2.1: hydrogenchloride / methanol / 1 h / 0 °C

With hydrogenchloride; HATU; In methanol; N,N-dimethyl-formamide;
DOI:10.2174/1570180811310070010