4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester)

Base Information

Chemical Name:4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester)
CAS No.:1383381-40-5
Molecular Formula:C₂₇H₃₅NO₅
Molecular Weight:453.579
Hs Code.:

Synonyms:4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester)

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Chemical Property of 4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester)

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Technology Process of 4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester)

There total 9 articles about 4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61413-54-5
Rolipram

: 1383381-39-2
isoperillyl chloroformate

: 1383381-40-5
4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester)

Guidance literature:: Rolipram; With n-butyllithium; In tetrahydrofuran; at -72 ℃; for 1.16667h; Inert atmosphere;

isoperillyl chloroformate; In tetrahydrofuran; at -72 ℃; for 3.16667h;

Reference yield:

: 19620-36-1
4-(propan-2-ylidene)cyclohexan-1-one

: 1383381-40-5
4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester)

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

2.1: aluminum isopropoxide / toluene / 7 h / Reflux

2.2: 20 °C

3.1: potassium carbonate / toluene / 10.75 h / 10 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 1.17 h / -72 °C / Inert atmosphere

4.2: 3.17 h / -72 °C

With n-butyllithium; potassium tert-butylate; aluminum isopropoxide; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; toluene;

Reference yield:

: 1383381-36-9
trifluoromethanesulfonic acid 4-isopropylidenecyclohex-1-enyl ester

: 1383381-40-5
4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester)

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Reflux

2.2: 5 °C

3.1: potassium carbonate / toluene / 10.75 h / 10 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 1.17 h / -72 °C / Inert atmosphere

4.2: 3.17 h / -72 °C

With lithium aluminium tetrahydride; n-butyllithium; potassium carbonate; triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;