5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine

Base Information

Chemical Name:5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine
CAS No.:1428248-90-1
Molecular Formula:C₂₆H₂₃F₅N₆
Molecular Weight:514.501
Hs Code.:

Synonyms:5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine

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Chemical Property of 5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine

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Technology Process of 5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine

There total 3 articles about 5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428248-69-4
5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

: 768-35-4
3-fluorophenylboronic acid

: 1428248-90-1
5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine

Guidance literature:: In 1,4-dioxane; water; at 100 ℃;
DOI:10.1016/j.bmcl.2021.128352

Reference yield:

: 1083051-56-2
6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

: 1428248-90-1
5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / Microwave irradiation

2: 1,4-dioxane; water / 100 °C

With potassium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2021.128352

Reference yield:

: 1428248-90-1
5-(3-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water; acetone;