D,L-m-Tyrosine Methyl Ester Hydrochloride

Base Information

• Chemical Name: D,L-m-Tyrosine Methyl Ester Hydrochloride
• CAS No.: 34260-70-3
• Molecular Formula: C₁₀H₁₃NO₃*ClH
• Molecular Weight: 231.679
• Mol file: 34260-70-3.mol

Synonyms:DL-Phenylalanine,3-hydroxy-, methyl ester, hydrochloride; Phenylalanine, 3-hydroxy-, methylester, hydrochloride (9CI); m-Tyrosine, methyl ester, hydrochloride, DL- (8CI);2-Amino-3-(3-hydroxyphenyl)propanoic acid methyl ester hydrochloride;DL-m-Tyrosine methyl ester hydrochloride

Chemical Property of D,L-m-Tyrosine Methyl Ester Hydrochloride

Chemical Property:

• Melting Point: 174-176°C
• PSA: 72.55000
• LogP: 1.93730
• Storage Temp.: Refrigerator
• Solubility.: Methanol, Water

Purity/Quality:

98%Min ^*data from raw suppliers

D,L-m-Tyrosine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D,L-m-Tyrosine Methyl Ester Hydrochloride is a m-tyrosine alkyl ester used in treatment of Parkinsonism A m-tyrosine alkyl ester used in treatment of Parkinsonism.

Technology Process of D,L-m-Tyrosine Methyl Ester Hydrochloride

There total 5 articles about D,L-m-Tyrosine Methyl Ester Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

m-tyrosine (587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2) → methyl (2S)-2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride (34260-70-3,34260-72-5,72683-79-5)

Guidance literature:

With thionyl chloride; In methanol; at 0 - 90 ℃; for 6h;

Reference yield: 99.0%

methanol (67-56-1) + m-tyrosine (587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2) → methyl (2S)-2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride (34260-70-3,34260-72-5,72683-79-5)

Guidance literature:

With acetyl chloride; Ambient temperature;

DOI:10.1055/s-1999-3119

Reference yield:

methanol (67-56-1) + N-formyl-L-m-hydroxyphenylalanine (72683-77-3) → methyl (2S)-2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride (34260-70-3,34260-72-5,72683-79-5)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) 100 deg C, 4 h;

DOI:10.1021/jm00178a013

upstream raw materials:

methanol

N-formyl-L-m-hydroxyphenylalanine

m-tyrosine

D/L-3-hydroxy-phenylalanine

Downstream raw materials:

(S)-3-Benzyloxycarbonylamino-N-[(S)-2-(3-hydroxy-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid benzyl ester

N-[6-(N-chlorambucilamino)hexanoyl]-L-m-tyrosine methyl ester

N-[6-(N-chlorambucilamino)hexanoyl]-L-m-tyrosinol

N-[11-(N-chlorambucilamino)undecanoyl]-L-m-tyrosine methyl ester

Refernces

• 1、 Descoteaux, Caroline,Brasseur, Kevin,Leblanc, Valerie,Parent, Sophie,Asselin, Eric,Berube, Gervais. "SAR study of tyrosine-chlorambucil hybrid regioisomers; Synthesis and biological evaluation against breast cancer cell lines". experimental part. p. 923 - 935. Retrieved 2012/10/07.
• 2、 Deaton, David N.,Graham, Kevin P.,Gross, Jeffrey W.,Miller, Aaron B.. "Thiol-based angiotensin-converting enzyme 2 inhibitors: P1′ modifications for the exploration of the S1′ subsite". . p. 1681 - 1687. Retrieved 2008/12/22.