N-naphthalen-1-yl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide

Base Information

Chemical Name:N-naphthalen-1-yl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide
CAS No.:5916-10-9
Molecular Formula:C₂₈H₃₂O₆
Molecular Weight:464.558
Hs Code.:
DSSTox Substance ID:DTXSID50415307
Wikidata:Q82224240

Synonyms:5916-10-9;CBMicro_015210;Oprea1_159412;Oprea1_172668;DTXSID50415307;STK122330;AKOS000565827;N-naphthalen-1-yl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide;BIM-0015195.P001;EU-0017789;AB00100694-01;SR-01000513341;SR-01000513341-1;N-(naphthalen-1-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide;N~1~-(1-naphthyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide

Suppliers and Price of N-naphthalen-1-yl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-naphthalen-1-yl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:385.09973129
Heavy Atom Count:28
Complexity:563

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=CC=C2NC(=O)CSC3=NC4=C(C5=CC=CC=C5N4)N=N3

Technology Process of N-naphthalen-1-yl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide

There total 17 articles about N-naphthalen-1-yl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 177949-92-7
(E)-4,4,5,5-tetramethyl-2-(3-methylbut-1-en-1-yl)-1,3,2-dioxaborolane

: 2-(2,4-dimethoxyphenyl)-5-hydroxy-6-iodo-7-methoxy-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

: 5916-10-9
(E)-2-(2,4-dimethoxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In 1,4-dioxane; water; at 100 ℃; for 9h; Solvent; Inert atmosphere;
DOI:10.3987/COM-15-S(T)42

Reference yield: 74.0%

: 1443276-25-2
2-(2,4-dimethoxyphenyl)-5-hydroxy-6-(1-hydroxy-3-methylbutyl)-7-methoxy-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

: 5916-10-9
(E)-2-(2,4-dimethoxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Guidance literature:: With sulfuric acid; for 3h; Reflux;
DOI:10.1016/j.tet.2013.05.024

Reference yield:

: 832-58-6
1-(2,4,6-trimethoxyphenyl)ethanone

: 5916-10-9
(E)-2-(2,4-dimethoxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / dichloromethane / 24 h / 0 °C / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.5 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 1.67 h / 0 °C / Reflux

4.1: potassium carbonate / acetone / 0.5 h

4.2: 24 h / Reflux

5.1: sulfuric acid / acetic acid / 0.5 h / 20 °C

6.1: methanol; sodium tetrahydroborate / 0.5 h

7.1: sulfuric acid / 3 h / Reflux

With methanol; aluminum (III) chloride; sodium tetrahydroborate; sulfuric acid; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; acetic acid; acetone; 3.1: |Baker-Venkataraman Rearrangement;
DOI:10.1016/j.tet.2013.05.024