4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide

Base Information

Chemical Name:4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide
CAS No.:80366-53-6
Molecular Formula:C₂₉H₂₇N₃O₆S₂
Molecular Weight:577.682
Hs Code.:

Synonyms:4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide

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Chemical Property of 4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide

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Technology Process of 4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide

There total 5 articles about 4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 57777-75-0
methanolamine hydrochloride

: 80366-51-4
4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-formylceph-3-em 1-oxide

: 80366-53-6
4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide

Guidance literature:: With pyridine; In tetrahydrofuran; ethanol; at 50 ℃; for 1h;
DOI:10.1248/cpb.31.1482

Reference yield:

: 70056-19-8
diphenylmethyl 7-(2-thienylacetamido)-2-methylene-3-acetoxymethylceph-3-em-4-carboxylate

: 80366-53-6
4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / Zn, formic acid / dimethylformamide / 20 h / Ambient temperature

2: 62 percent / 2 N HCl / dimethylformamide / 20 h / Ambient temperature

3: 36.2 percent / CrO₃, pyridine / CH₂Cl₂ / 0.08 h / 15 - 20 °C

4: 50 percent / MCPBA / CH₂Cl₂ / 1 h / Ambient temperature

5: 80 percent / pyridine / tetrahydrofuran; ethanol / 1 h / 50 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; formic acid; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.31.1482

Reference yield:

: 80366-17-2
diphenylmethyl 7-(2-thienylacetamido)-2-methyl-3-hydroxymethyl-ceph-2-em-4-carboxylate

: 80366-53-6
4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 36.2 percent / CrO₃, pyridine / CH₂Cl₂ / 0.08 h / 15 - 20 °C

2: 50 percent / MCPBA / CH₂Cl₂ / 1 h / Ambient temperature

3: 80 percent / pyridine / tetrahydrofuran; ethanol / 1 h / 50 °C

With pyridine; chromium(VI) oxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1248/cpb.31.1482