diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate

Base Information

Chemical Name:diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate
CAS No.:80366-54-7
Molecular Formula:C₂₉H₂₇N₃O₅S₂
Molecular Weight:561.682
Hs Code.:

Synonyms:diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate

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Chemical Property of diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate

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Technology Process of diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate

There total 6 articles about diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 80366-53-6
4-(1,1-diphenylmethoxycarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em 1-oxide

: 80366-54-7
diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate

Guidance literature:: With phosphorus trichloride; In N,N-dimethyl-formamide; at -20 ℃; for 0.75h;
DOI:10.1248/cpb.31.1482

Reference yield:

: 70056-19-8
diphenylmethyl 7-(2-thienylacetamido)-2-methylene-3-acetoxymethylceph-3-em-4-carboxylate

: 80366-54-7
diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 57 percent / Zn, formic acid / dimethylformamide / 20 h / Ambient temperature

2: 62 percent / 2 N HCl / dimethylformamide / 20 h / Ambient temperature

3: 36.2 percent / CrO₃, pyridine / CH₂Cl₂ / 0.08 h / 15 - 20 °C

4: 50 percent / MCPBA / CH₂Cl₂ / 1 h / Ambient temperature

5: 80 percent / pyridine / tetrahydrofuran; ethanol / 1 h / 50 °C

6: 90 percent / PCl₃ / dimethylformamide / 0.75 h / -20 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; formic acid; 3-chloro-benzenecarboperoxoic acid; zinc; phosphorus trichloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.31.1482

Reference yield:

: 80366-17-2
diphenylmethyl 7-(2-thienylacetamido)-2-methyl-3-hydroxymethyl-ceph-2-em-4-carboxylate

: 80366-54-7
diphenyl 7-(2-thienylacetamido)-2α-methyl-3-methoxyiminomethylceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 36.2 percent / CrO₃, pyridine / CH₂Cl₂ / 0.08 h / 15 - 20 °C

2: 50 percent / MCPBA / CH₂Cl₂ / 1 h / Ambient temperature

3: 80 percent / pyridine / tetrahydrofuran; ethanol / 1 h / 50 °C

4: 90 percent / PCl₃ / dimethylformamide / 0.75 h / -20 °C

With pyridine; chromium(VI) oxide; 3-chloro-benzenecarboperoxoic acid; phosphorus trichloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.31.1482