4-CYANOPIPERIDINE HCL

Base Information

• Chemical Name: 4-CYANOPIPERIDINE HCL
• CAS No.: 240401-22-3
• Molecular Formula: C6H10 N2 . Cl H
• Molecular Weight: 146.62
• Hs Code.: 2933399090
• Mol file: 240401-22-3.mol

Synonyms:4-Piperidinecarbonitrile,monohydrochloride (9CI); Piperidine-4-carbonitrile hydrochloride

Chemical Property of 4-CYANOPIPERIDINE HCL

Chemical Property:

• PSA: 35.82000
• LogP: 1.64038
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Piperidine-4-carbonitrileHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Piperidine-4-carbonitrile hydrochloride is a useful research chemical.

Technology Process of 4-CYANOPIPERIDINE HCL

There total 5 articles about 4-CYANOPIPERIDINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

4-carboxamidopiperidine (39546-32-2) → piperidine-4-carbonitrile hydrochloride (240401-22-3)

Guidance literature:

With thionyl chloride; N,N-dibutylformamide; In toluene; at 20 ℃; for 18h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

1-tert-butoxycarbonyl-4-cyanopiperidine (91419-52-2) → piperidine-4-carbonitrile hydrochloride (240401-22-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.75h;

Reference yield:

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine (178308-63-9) → piperidine-4-carbonitrile hydrochloride (240401-22-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine;

upstream raw materials:

1-tert-butoxycarbonyl-4-cyanopiperidine

1-methyl-pyrrolidin-2-one

1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine

4-carboxamidopiperidine

Downstream raw materials:

1-tert-butoxycarbonyl-4-cyanopiperidine

2-methylpropyl 2-(4-{4-[(4-cyanopiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl}phenyl)-1H-imidazole-1-carboxylate