C₁₆H₂₂O₃

Base Information

• Chemical Name: C₁₆H₂₂O₃
• CAS No.: 381226-52-4
• Molecular Formula: C₁₆H₂₂O₃
• Molecular Weight: 262.349
• Mol file: 381226-52-4.mol

Synonyms:C₁₆H₂₂O₃

Chemical Property of C₁₆H₂₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₂O₃

There total 5 articles about C₁₆H₂₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + C13H17IO → C16H22O3 (381226-52-4)

Guidance literature:

ethanol; carbon monoxide; C₁₃H₁₇IO; With dimanganese decacarbonyl; potassium hydrogencarbonate; at 20 ℃; for 24h; under 7600.51 Torr; Sealed tube; Glovebox;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 1h; Sealed tube; Glovebox;

DOI:10.1021/acs.orglett.6b02154

Reference yield:

C16H18O3 (381226-51-3) → C16H22O3 (381226-52-4)

Guidance literature:

With hydrogen; 4% Pd/C; In ethanol; at 20 ℃; for 8h; under 258.581 Torr;

Reference yield:

methyl 2-(4-methoxyphenyl)hex-5-enoate → C16H22O3 (381226-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C

2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C

3.1: potassium hydrogencarbonate; dimanganese decacarbonyl / 4 h / 20 °C / 7600.51 Torr / Sealed tube; Glovebox

3.2: 1 h / Sealed tube; Glovebox

With 1H-imidazole; lithium aluminium tetrahydride; dimanganese decacarbonyl; iodine; potassium hydrogencarbonate; triphenylphosphine; In diethyl ether; dichloromethane;

DOI:10.1021/acs.orglett.6b02154

upstream raw materials:

C₁₆H₁₈O₃

4-methoxy-phenyl acetic acid methyl ester

ethanol

carbon monoxide