4-acetylphenyl N,N-dimethylsulfamate

Base Information

• Chemical Name: 4-acetylphenyl N,N-dimethylsulfamate
• CAS No.: 1432739-32-6
• Molecular Formula: C₁₀H₁₃NO₄S
• Molecular Weight: 243.284
• Mol file: 1432739-32-6.mol

Synonyms:4-acetylphenyl N,N-dimethylsulfamate

Chemical Property of 4-acetylphenyl N,N-dimethylsulfamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-acetylphenyl N,N-dimethylsulfamate

There total 1 articles about 4-acetylphenyl N,N-dimethylsulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

dimethylamino sulfonyl chloride (13360-57-1) + 4-Hydroxyacetophenone (99-93-4) → 4-acetylphenyl N,N-dimethylsulfamate (1432739-32-6)

Guidance literature:

4-Hydroxyacetophenone; With sodium hydride; In 1,2-dimethoxyethane; mineral oil; at 0 - 20 ℃; for 0.166667h;

dimethylamino sulfonyl chloride; at 0 - 20 ℃; for 16h; Enzymatic reaction;

DOI:10.1021/ol401021x

Reference yield: 95.0%

4-acetylphenyl N,N-dimethylsulfamate (1432739-32-6) + bis(2-methylphenyl)borinic acid (73774-44-4) → 4-acetyl-2'-methylbiphenyl (56917-39-6)

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; potassium phosphate tribasic trihydrate; 1-n-butyl-3-methylimidazolim bromide; In toluene; at 110 ℃; for 10h; Inert atmosphere;

DOI:10.1021/jo501291y

Reference yield: 93.0%

4-acetylphenyl N,N-dimethylsulfamate (1432739-32-6) + bis(2-ethylphenyl)borinic acid (1519010-69-5) → 1-(2′-ethylbiphenyl-4-yl)ethanone

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; potassium phosphate tribasic trihydrate; 1-n-butyl-3-methylimidazolim bromide; In toluene; at 110 ℃; for 10h; Inert atmosphere;

DOI:10.1021/jo501291y

upstream raw materials:

dimethylamino sulfonyl chloride

4-Hydroxyacetophenone

Downstream raw materials:

tert-butyl 4-acetylbenzylcarbamate

tert-butyl (4-acetylbenzyl)(butyl)carbamate

1-(4'-methoxy-biphenyl-4-yl)-ethanone

biphenyl-4-acetaldehyde

Refernces

• 1、 Molander, Gary A.,Shin, Inji. "Pd-catalyzed Suzuki-Miyaura cross-coupling reactions between sulfamates and potassium Boc-protected aminomethyltrifluoroborates". supporting information. p. 2534 - 2537. Retrieved 2013/06/27.