(4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Base Information

Chemical Name:(4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene
CAS No.:530147-43-4
Molecular Formula:C₄₅H₈₄O₃Si₃
Molecular Weight:757.417
Hs Code.:

(4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Synonyms:(4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Suppliers and Price of (4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

There total 9 articles about (4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 144699-08-1
3,5-di[(tert-butyldimethylsilyl)oxy]-1-ethynylcyclohex-1-ene

: 530147-06-9
(6R)-2-methyl-6-[(1R,4aR,8aR)-5-(trifluoromethanesulfonyloxy)-8a-methyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthyl]-2-(triethylsilyloxy)heptane

: 530147-43-4
(4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Guidance literature:: With copper(l) iodide; diethylamine; bis(triphenylphosphine) palladium (Il) acetate; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1039/b209147j

Reference yield:

: 2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propionitrile

: 530147-43-4
(4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Guidance literature:: Multi-step reaction with 10 steps

1.1: 64 percent / DIBAL-H / diethyl ether; hexane; toluene / -78 - 0 °C

2.1: 92 percent / pyridine / 0 °C

3.1: borane-tetrahydrofuran complex / tetrahydrofuran / -20 °C

3.2: NaOH; H₂O₂ / tetrahydrofuran; H₂O / -30 - 20 °C

4.1: 93 percent / sodium iodide / acetone / 60 °C

5.1: pyridine; zinc; NiCl₂ / 0.75 h / 65 °C

5.2: 86 percent / pyridine / 1.5 h / 20 °C

6.1: 93 percent / tetrahydrofuran; diethyl ether / 1 h / 20 °C

7.1: pyridinium dichromate / CH₂Cl₂ / 20 °C

8.1: 88 percent / imidazole / CH₂Cl₂ / 3 h / 20 °C

9.1: i-Pr₂NH; n-BuLi / tetrahydrofuran; hexane / 2.75 h / -78 - 20 °C

9.2: 81 percent / tetrahydrofuran / 4.17 h / -78 - 20 °C

10.1: 91 percent / CuI; Et₂NH / Pd(PPh₃)2(OAc)2 / acetonitrile / 1 h / 20 °C

With pyridine; 1H-imidazole; copper(l) iodide; dipyridinium dichromate; n-butyllithium; borane-THF; diisobutylaluminium hydride; diethylamine; diisopropylamine; sodium iodide; nickel dichloride; zinc; bis(triphenylphosphine) palladium (Il) acetate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetone; toluene; acetonitrile;
DOI:10.1039/b209147j

Reference yield:

: (4aR,5R)-5-((R)-2-Iodo-1-methyl-ethyl)-4a-methyl-decahydro-naphthalen-1-ol

: 530147-43-4
(4R,4aR,8aR)-8-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-4-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-4a-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; zinc; NiCl₂ / 0.75 h / 65 °C

1.2: 86 percent / pyridine / 1.5 h / 20 °C

2.1: 93 percent / tetrahydrofuran; diethyl ether / 1 h / 20 °C

3.1: pyridinium dichromate / CH₂Cl₂ / 20 °C

4.1: 88 percent / imidazole / CH₂Cl₂ / 3 h / 20 °C

5.1: i-Pr₂NH; n-BuLi / tetrahydrofuran; hexane / 2.75 h / -78 - 20 °C

5.2: 81 percent / tetrahydrofuran / 4.17 h / -78 - 20 °C

6.1: 91 percent / CuI; Et₂NH / Pd(PPh₃)2(OAc)2 / acetonitrile / 1 h / 20 °C

With pyridine; 1H-imidazole; copper(l) iodide; dipyridinium dichromate; n-butyllithium; diethylamine; diisopropylamine; nickel dichloride; zinc; bis(triphenylphosphine) palladium (Il) acetate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetonitrile;
DOI:10.1039/b209147j