methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate

Base Information

Chemical Name:methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate
CAS No.:1259286-15-1
Molecular Formula:C₁₈H₂₅NO₄S
Molecular Weight:351.467
Hs Code.:

Synonyms:methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate

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Technology Process of methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate

There total 4 articles about methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1259286-14-0
methyl (2S)-2-[[(4-methoxyphenyl)methyl]amino]-4-(methylsulfinyl)butanoate

: 3355-28-0
1-Bromo-2-butyne

: 1259286-15-1
methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 23h; Inert atmosphere;
DOI:10.1021/jo101790z

Reference yield:

: 1259286-13-9
methyl (2S)-2-[[(4-methoxyphenyl)methyl]amino]-4-(methylthio)butanoate

: 1259286-15-1
methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate / methanol; water / 3.5 h / 20 °C / Cooling with ice

2: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere

With sodium periodate; tetra-(n-butyl)ammonium iodide; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo101790z

Reference yield:

: 63-68-3,26062-47-5,58576-49-1
L-methionine

: 1259286-15-1
methyl (2S)-2-[[(4-methoxyphenyl)methyl]-(2-butyn-1-yl)-amino]-4-(methylsulfinyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: acetyl chloride / Reflux

2: sodium tris(acetoxy)borohydride; triethylamine / 1,2-dichloro-ethane / 19 h / 20 °C / Inert atmosphere

3: sodium periodate / methanol; water / 3.5 h / 20 °C / Cooling with ice

4: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere

With sodium periodate; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; acetyl chloride; In methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo101790z