Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester

Base Information

• Chemical Name: Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester
• CAS No.: 123796-66-7
• Molecular Formula: C₂₈H₃₃NO₇
• Molecular Weight: 495.573
• Mol file: 123796-66-7.mol

Synonyms:Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester

Chemical Property of Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester

There total 14 articles about Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

acetic anhydride (108-24-7) + 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol (123796-65-6) → Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester (123796-66-7)

Guidance literature:

With pyridine; at 35 - 40 ℃; for 2.5h;

DOI:10.1039/P19910000841

Reference yield:

Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate (123796-63-4) → Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester (123796-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / NH₄OAc / acetic acid / 1.5 h / 80 °C

2: 82 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

3: 87 percent / pyridine / 2.5 h / 35 - 40 °C

With lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran; pyridine; acetic acid;

DOI:10.1039/c39890000301

Reference yield:

1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester (123796-64-5) → Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester (123796-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

2: 87 percent / pyridine / 2.5 h / 35 - 40 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; pyridine;

DOI:10.1039/c39890000301

upstream raw materials:

acetic anhydride

1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol

Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate

1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester

Downstream raw materials:

ancistrocladisine

N-<2-<4-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide