2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene

Base Information

• Chemical Name: 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene
• CAS No.: 307306-06-5
• Molecular Formula: C₂₅H₁₈Cl₂F₂O₅
• Molecular Weight: 507.318

Synonyms:2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene

Chemical Property of 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene

Chemical Property:

Purity/Quality:

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Technology Process of 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene

There total 8 articles about 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-bromo-1,4-difluorobenzene (399-94-0) + 3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride (21740-23-8) → 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene (307306-06-5) + 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-α-D-ribofuranosyl]]benzene (307306-05-4)

Guidance literature:

2-bromo-1,4-difluorobenzene; With magnesium; In tetrahydrofuran; at 40 ℃; for 1h;

With cadmium(II) chloride; In tetrahydrofuran; for 1h; Heating;

3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1139/cjc-78-8-1081

Reference yield: 49.0%

1,4-difluoro-2-iodobenzene (2265-92-1) + 3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride (21740-23-8) → 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene (307306-06-5) + 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-α-D-ribofuranosyl]]benzene (307306-05-4)

Guidance literature:

3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride; With iodine; magnesium; In tetrahydrofuran; at 40 ℃; for 1h;

With cadmium(II) chloride; for 1h; Heating;

1,4-difluoro-2-iodobenzene; at 25 ℃; for 12h;

DOI:10.1081/NCN-100001435

Reference yield: 19.0%

2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-α-D-ribofuranosyl]]benzene (307306-05-4) → 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene (307306-06-5)

Guidance literature:

With boron trifluoride diethyl etherate; In various solvent(s); at 120 ℃; for 2h;

DOI:10.1081/NCN-100001435

upstream raw materials:

1,4-difluoro-2-iodobenzene

3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-α-D-ribofuranosyl]]benzene

2-bromo-1,4-difluorobenzene

Downstream raw materials:

C₂₅H₁₇Cl₂F₂NO₇

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