4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester
• CAS No.: 133052-65-0
• Molecular Formula: C₁₅H₁₃FN₂O₄
• Molecular Weight: 304.278
• Mol file: 133052-65-0.mol

Synonyms:4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester

Chemical Property of 4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester

There total 1 articles about 4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Difluoronitrobenzene (446-35-5) + methyl 4-(aminomethyl)benzoate (18469-52-8) → 4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester (133052-65-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

DOI:10.1021/jm00083a011

Reference yield:

4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester (133052-65-0) → 4-[(2-Amino-5-fluoro-phenylamino)-methyl]-benzoic acid methyl ester

Guidance literature:

With tin(ll) chloride; In methanol; for 10h; Heating;

DOI:10.1021/jm00083a011

Reference yield:

4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester (133052-65-0) → 4-(2-Butyl-6-fluoro-benzoimidazol-1-ylmethyl)-benzoic acid (133052-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tin(II) chloride dihydrate / methanol / 10 h / Heating

2: p-toluenesulfonic acid monohydrate, valeric acid / toluene / 10 h / Heating

3: aq. NaOH / ethanol / 3 h / Heating

With sodium hydroxide; toluene-4-sulfonic acid; tin(ll) chloride; valeric acid; In methanol; ethanol; toluene;

DOI:10.1021/jm00083a011

upstream raw materials:

2,4-Difluoronitrobenzene

methyl 4-(aminomethyl)benzoate

Downstream raw materials:

4-(2-Butyl-6-fluoro-benzoimidazol-1-ylmethyl)-benzoic acid

methyl 4-[(2-butyl-6-fluoro-1H-benzimidazol-1-yl)methyl]benzoate