tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate
CAS No.:1187321-34-1
Molecular Formula:C₁₉H₂₇FN₂O₄
Molecular Weight:366.433
Hs Code.:

Synonyms:tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 917834-41-4
tert-butyl 4-(benzyloxycarbonylamino)-4-(hydroxymethyl)piperidine-1-carboxylate

: 1187321-34-1
tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 5 ℃; for 3h;

Reference yield:

: 1093214-64-2
1-(tert-butoxycarbonyl)-4-(ethoxycarbonyl)piperidine-4-carboxylic acid

: 1187321-34-1
tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.75 h / 20 °C

1.2: 20 h / 80 °C

2.1: hydrogen / 5%-palladium/activated carbon / ethanol / 2.25 h

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 0 - 5 °C

3.2: 0.25 h / 0 - 5 °C

4.1: triethylamine / tetrahydrofuran / 0 - 20 °C

5.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 5 °C / Inert atmosphere

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; diphenyl phosphoryl azide; hydrogen; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1187321-31-8
4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester

: 1187321-34-1
tert-butyl 4-(benzyloxycarbonylamino)-4-(fluoromethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethanol / 2.25 h

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 0 - 5 °C

2.2: 0.25 h / 0 - 5 °C

3.1: triethylamine / tetrahydrofuran / 0 - 20 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 5 °C / Inert atmosphere

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; hydrogen; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; dichloromethane;