4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine

Base Information

• Chemical Name: 4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine
• CAS No.: 195965-78-7
• Molecular Formula: C₂₈H₄₄N₂O₄Si₂
• Molecular Weight: 528.839
• Mol file: 195965-78-7.mol

Synonyms:4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine

Chemical Property of 4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine

There total 2 articles about 4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

chloro-trimethyl-silane (75-77-4) + 3,3'-Bis-morpholin-4-ylmethyl-biphenyl-2,2'-diol (195965-70-9) → 4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine (195965-78-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In diethyl ether; for 6h;

DOI:10.1021/jo970372z

Reference yield:

2,2'-dihydroxybiphenyl (1806-29-7) → 4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine (195965-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / dioxane / 1.) room temperature, 2 h, 2.) reflux, 4 h

2: 93 percent / Et₃N, DBU / diethyl ether / 6 h

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In 1,4-dioxane; diethyl ether;

DOI:10.1021/jo970372z

Reference yield:

4-(2-[(trimethylsilyl)oxy]-3-{2-[(trimethylsilyl)oxy]-3-(morpholinomethyl)phenyl}benzyl)morpholine (195965-78-7) → 3,3'-Bis-((1R,2S,5R)-1-hydroxy-2-isopropyl-5-methyl-cyclohexylmethyl)-biphenyl-2,2'-diol (195965-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / phenylchloroformate / CH₂Cl₂ / 3 h / 0 °C

2: 90 percent / SmI₂ / tetrahydrofuran / 2 h / Ambient temperature

With samarium diiodide; phenyl chloroformate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo970372z

upstream raw materials:

chloro-trimethyl-silane

3,3'-Bis-morpholin-4-ylmethyl-biphenyl-2,2'-diol

2,2'-dihydroxybiphenyl

Downstream raw materials:

3,3'-Bis-((1R,2S,5R)-1-hydroxy-2-isopropyl-5-methyl-cyclohexylmethyl)-biphenyl-2,2'-diol