6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde

Base Information

Chemical Name:6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde
CAS No.:582313-93-7
Molecular Formula:C₂₇H₂₉NO₄
Molecular Weight:431.532
Hs Code.:

Synonyms:6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde

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Chemical Property of 6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde

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Technology Process of 6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde

There total 7 articles about 6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {6-[2-((3aS,6aR)-5-Benzyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-yl)-ethoxy]-naphthalen-2-yl}-methanol

: 582313-93-7
6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;
DOI:10.1248/cpb.51.276

Reference yield:

: 17295-12-4
ethyl 6-hydroxy-2-naphthoate

: 582313-93-7
6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / Ph₃P; DEAD / tetrahydrofuran / 24 h / 20 °C

2: DIBAL-H / CH₂Cl₂ / 1 h / -78 - 0 °C

3: 158 mg / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

With diisobutylaluminium hydride; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1248/cpb.51.276

Reference yield:

: 100-52-7
benzaldehyde

: 582313-93-7
6-[2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethoxy]naphthalene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / NaBH₃CN; AcOH / methanol / 24 h / 20 °C

2: 86 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

3: 74 percent / Ph₃P; DEAD / tetrahydrofuran / 24 h / 20 °C

4: DIBAL-H / CH₂Cl₂ / 1 h / -78 - 0 °C

5: 158 mg / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

With diisobutylaluminium hydride; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1248/cpb.51.276