5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole

Base Information

• Chemical Name: 5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole
• CAS No.: 143682-61-5
• Molecular Formula: C₂₄H₂₈N₂O
• Molecular Weight: 360.499
• Mol file: 143682-61-5.mol

Synonyms:5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole

Chemical Property of 5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole

There total 6 articles about 5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(5-methoxy-1H-indol-3-yl)-4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butane-1,4-dione (227202-63-3) → 5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole (143682-61-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1016/S0960-894X(99)00135-3

Reference yield:

4-(5-Methoxy-1H-indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butan-1-one (143682-32-0) → 5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole (143682-61-5)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jm00100a006

Reference yield:

4-(5-methoxy-1H-indol-3-yl)butyric acid (83696-90-6) → 5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole (143682-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 1 h, 2.) THF, RT, overnight

2: dihydrobis(methoxyethanato-O,O')aluminate sodium / tetrahydrofuran / 2 h / Ambient temperature

With sodium bis(2-methoxyethoxy)aluminium dihydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1021/jm00100a006

upstream raw materials:

4-(5-Methoxy-1H-indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butan-1-one

1-(5-methoxy-1H-indol-3-yl)-4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butane-1,4-dione

5-methoxylindole

4-(5-methoxy-indol-3-yl)-4-oxo-butyric acid

Downstream raw materials:

roxindole