83696-90-6

Usage

Uses

Used in Pharmaceutical Industry:
4-(5-METHOXY-1H-INDOL-3-YL)-BUTYRIC ACID is used as a therapeutic agent for the treatment of mental health disorders such as depression and anxiety. Its mood-regulating, sleep-promoting, and stress-relieving properties make it a promising candidate for pharmaceutical applications.
Used in Nutraceutical Industry:
4-(5-METHOXY-1H-INDOL-3-YL)-BUTYRIC ACID is used as a nutraceutical ingredient for its antioxidant and anti-inflammatory properties. It can be incorporated into wellness products to support overall health and well-being.
Used in Sleep Aid Products:
4-(5-METHOXY-1H-INDOL-3-YL)-BUTYRIC ACID is used as a precursor to melatonin in sleep aid products, helping to regulate the sleep-wake cycle and improve sleep quality.
Used in Antioxidant and Anti-Inflammatory Formulations:
4-(5-METHOXY-1H-INDOL-3-YL)-BUTYRIC ACID is used as an active ingredient in antioxidant and anti-inflammatory formulations, targeting various health conditions and promoting overall health.

InChI:InChI=1/C13H15NO3/c1-17-10-5-6-12-11(7-10)9(8-14-12)3-2-4-13(15)16/h5-8,14H,2-4H2,1H3,(H,15,16)

Upstream product

• 96-48-0 4-butanolide 
• 1006-94-6 5-methoxylindole 
• 83706-89-2 C₁₆H₂₀N₂O₄ 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 104-94-9 4-methoxy-aniline 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 27983-42-2 5-carboethoxypentanal 
• 83696-88-2 ethyl 4-(2-ethoxycarbonyl-5-methoxyindol-3-yl)butanoate 
• 83706-90-5 6-carboethoxy-6-p-methoxyphenylhydrazonohexanoic acid 
• 83706-89-2 ethyl 1-(4-methoxyphenylazo)-2-oxocyclohexanecarboxylate 
• 83696-89-3 4-(2-carboxy-5-methoxyindol-3-yl)butanoic acid 

Downstream Products

• 3449-49-8 6-methoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 13070-45-6 6-Methoxy-1,2,3,4-tetrahydrocarbazole 
• 143682-61-5 5-methoxy-3-[3-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole 
• 112192-04-8 roxindole 

Relevant academic research and scientific papers

Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations

We describe asymmetric intramolecular Friedel-Crafts alkylations with a DNA-based hybrid catalyst and propose a plausible binding model. This study shows promise for studying relationships between the helical chirality of DNA and enantioselectivity of the chemical reaction.

A Simple Procedure for Synthesis of Roxindole, a Dopamine D2-Receptor Agonist

A modified convenient and high yielding synthetic route for the preparation of the dopamine agonist roxindole 1 is described. The key step in our method is the phase-transfer catalyzed reaction of γ-butyrolactone with 5-methoxyindole which results in the indolylbutyric acid derivative directly in one step.

Electrophilic Substitution in Indoles. Part 11. The Mechanism of Substitution in 5-Methoxyindoles

Deuterium labelling experiments show that the boron trifluoride-catalysed cyclisation at 90 deg C of 4-(5-methoxyindole-3-yl)butanol (1e) to 6-methoxytetrahydrocarbazole (11a) occurs by two simultaneous pathways.The main route (83.5percent) involves initial cyclisation at the 3-position of (1e) to give an intermediate spirocyclic indolenine which then rearranges to the tetrahydrocarbazole.The minor pathway (16.5percent) involves direct attack at the 2-position.A similar duality of mechanism of substitution applies to the 6-methoxy-, 4,6-dimethoxy-, and 5,6-dimethoxy-indole analogues for which the extent of substitution at the 2-position can be correlated with the calculated change in ?-electron density at the 2- and 3-positions for a series of methoxy-substituted 3-methyl-indoles.These calculations do not, however, fit the experimental findings for the 5-methoxy-derivative which appears to be anomalous, showing an unexpectedly high percentage of direct substitution at the 2-position.A possible explanation of this result is advanced.