5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine

Base Information

Chemical Name:5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine
CAS No.:1167437-34-4
Molecular Formula:C₁₅H₁₀F₃N₅O₂
Molecular Weight:349.272
Hs Code.:

Synonyms:5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine

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Chemical Property of 5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine

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Technology Process of 5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine

There total 2 articles about 5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1167437-09-3
3-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-phenyl-1H-pyrazole

: 6945-68-2
5-bromo-3-nitro-pyridin-2-ylamine

: 1167437-34-4
5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium formate; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1039/b901024f

Reference yield: 30.0%

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 1167437-49-1
5-[4-bromo-3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine

: 1167437-34-4
5-[3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine

: 1167437-52-6
5-[3-(trifluoromethyl)-4-(6-(trifluoromethyl)pyridin-3-yl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine

Guidance literature:: 6-(trifluoromethyl)-3-pyridinylboronic acid; 5-[4-bromo-3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-yl]-3-nitropyridin-2-amine; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 20 ℃; for 0.166667h; Inert atmosphere;

With sodium carbonate; In 1,4-dioxane; water; for 3.5h; Reflux; Inert atmosphere;
DOI:10.1039/b901024f