N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Base Information

Chemical Name:N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide
CAS No.:178986-39-5
Molecular Formula:C₃₈H₅₁NO₉
Molecular Weight:665.824
Hs Code.:

Synonyms:N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Suppliers and Price of N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

There total 7 articles about N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 178986-38-4
N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

: 178986-39-5
N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Guidance literature:: With chloro-trimethyl-silane; 3 A molecular sieve; sodium cyanoborohydride; In toluene; acetonitrile; for 24h; Ambient temperature;
DOI:10.1016/0968-0896(96)00064-8

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 178986-39-5
N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / p-toluenesulfonic acid / dimethylformamide / 3 h / 60 °C

2: 87 percent / BaO, Ba(OH)2 / dimethylformamide / 12 h / Ambient temperature

3: 35 percent / NaCNBH₃, 3 A molecular sieves, trimethylsilyl chloride / acetonitrile; toluene / 24 h / Ambient temperature

With barium dihydroxide; chloro-trimethyl-silane; 3 A molecular sieve; sodium cyanoborohydride; toluene-4-sulfonic acid; barium(II) oxide; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/0968-0896(96)00064-8

Reference yield:

: 121692-14-6
8-p-methoxyphenoxyloctanol

: 178986-39-5
N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Hg(CN)2, CaSO₄ / 1.) toluene, RT, 1 h, 2.) toluene, 4 d

2: NaOMe, MeOH / 24 h / Ambient temperature

3: 87 percent / p-toluenesulfonic acid / dimethylformamide / 3 h / 60 °C

4: 87 percent / BaO, Ba(OH)2 / dimethylformamide / 12 h / Ambient temperature

5: 35 percent / NaCNBH₃, 3 A molecular sieves, trimethylsilyl chloride / acetonitrile; toluene / 24 h / Ambient temperature

With methanol; calcium sulfate; barium dihydroxide; chloro-trimethyl-silane; 3 A molecular sieve; sodium methylate; mercury(II) cyanide; sodium cyanoborohydride; toluene-4-sulfonic acid; barium(II) oxide; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/0968-0896(96)00064-8