N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

Base Information

Chemical Name:N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide
CAS No.:178986-38-4
Molecular Formula:C₃₈H₄₉NO₉
Molecular Weight:663.808
Hs Code.:

Synonyms:N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

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Chemical Property of N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

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Technology Process of N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

There total 6 articles about N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 100-39-0
benzyl bromide

: 178986-37-3
N-[(2R,4aR,6R,7R,8R,8aS)-8-Hydroxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

: 178986-38-4
N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

Guidance literature:: With barium dihydroxide; barium(II) oxide; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1016/0968-0896(96)00064-8

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 178986-38-4
N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / p-toluenesulfonic acid / dimethylformamide / 3 h / 60 °C

2: 87 percent / BaO, Ba(OH)2 / dimethylformamide / 12 h / Ambient temperature

With barium dihydroxide; toluene-4-sulfonic acid; barium(II) oxide; In N,N-dimethyl-formamide;
DOI:10.1016/0968-0896(96)00064-8

Reference yield:

: 121692-14-6
8-p-methoxyphenoxyloctanol

: 178986-38-4
N-[(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Hg(CN)2, CaSO₄ / 1.) toluene, RT, 1 h, 2.) toluene, 4 d

2: NaOMe, MeOH / 24 h / Ambient temperature

3: 87 percent / p-toluenesulfonic acid / dimethylformamide / 3 h / 60 °C

4: 87 percent / BaO, Ba(OH)2 / dimethylformamide / 12 h / Ambient temperature

With methanol; calcium sulfate; barium dihydroxide; sodium methylate; mercury(II) cyanide; toluene-4-sulfonic acid; barium(II) oxide; In N,N-dimethyl-formamide;
DOI:10.1016/0968-0896(96)00064-8