C₆₀H₈₂N₁₀O₁₆

Base Information

• Chemical Name: C₆₀H₈₂N₁₀O₁₆
• CAS No.: 1258973-64-6
• Molecular Formula: C₆₀H₈₂N₁₀O₁₆
• Molecular Weight: 1199.37
• Mol file: 1258973-64-6.mol

Synonyms:C₆₀H₈₂N₁₀O₁₆

Chemical Property of C₆₀H₈₂N₁₀O₁₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₀H₈₂N₁₀O₁₆

There total 4 articles about C₆₀H₈₂N₁₀O₁₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-74-8) + 2,7-bis{3-[(3-aminophenyl)carbamoyl]propoxy}naphthalene (109217-64-3) → C60H82N10O16 (1258973-64-6)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1002/cmdc.201000308

Reference yield:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide (131308-91-3) → C60H82N10O16 (1258973-64-6)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

3: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201000308

Reference yield:

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-70-4) → C60H82N10O16 (1258973-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201000308

upstream raw materials:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester

2,7-bis{3-[(3-aminophenyl)carbamoyl]propoxy}naphthalene