2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide

Base Information

Chemical Name:2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide
CAS No.:1421851-03-7
Molecular Formula:C₁₄H₂₀Cl₃NO₄
Molecular Weight:372.676
Hs Code.:

Synonyms:2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide

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Chemical Property of 2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide

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Technology Process of 2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide

There total 3 articles about 2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1421851-02-6
2,2,2-trichloro-N-((1R)-6-(dimethoxymethyl)-4-methyl-2-oxo-1-vinylcyclohex-3-en-1-yl)acetamide

: 1421851-03-7
2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 0.5h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo302773f

Reference yield:

: C₁₂H₁₂Cl₃NO₃

: 1421851-03-7
2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: CSA / methanol / 1 h / 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 °C / Inert atmosphere

With diisobutylaluminium hydride; In methanol; dichloromethane; toluene;
DOI:10.1021/jo302773f

Reference yield:

: 271256-59-8
2,2,2-Trichloro-N-[(1R,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-2-oxo-1-vinyl-cyclohex-3-enyl]-acetamide

: 1421851-03-7
2,2,2-trichloro-N-((1R,2R)-6-(dimethoxymethyl)-2-hydroxy-4-methyl-1-vinylcyclohex-3-en-1-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: periodic acid dihydrate / ethyl acetate / 4 h / 20 °C / Inert atmosphere

2: CSA / methanol / 1 h / 20 °C / Inert atmosphere

3: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 °C / Inert atmosphere

With periodic acid dihydrate; diisobutylaluminium hydride; In methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo302773f