(+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Base Information

• Chemical Name: (+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione
• CAS No.: 340961-59-3
• Molecular Formula: C₂₁H₂₁N₃O₄
• Molecular Weight: 379.415

Synonyms:(+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Chemical Property of (+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

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Technology Process of (+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

There total 1 articles about (+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Amino-4,5-dimethoxybenzoic acid (5653-40-7) + 1-benzyl-3-methylpiperazine-2,5-dione → (+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione (340961-59-3)

Guidance literature:

1-benzyl-3-methylpiperazine-2,5-dione; With triethyloxonium fluoroborate; sodium carbonate; In dichloromethane; at 20 ℃;

2-Amino-4,5-dimethoxybenzoic acid; at 110 ℃; for 4h;

DOI:10.1016/S0957-4166(01)00067-2

Reference yield: 68.0%

Vilsmeier reagent (3724-43-4,149409-22-3) + (+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione (340961-59-3) → (S)-2-Benzyl-1-[1-dimethylamino-meth-(Z)-ylidene]-6,7-dimethoxy-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4020(01)00046-1

Reference yield: 67.0%

bis-(dimethylamino)methane (51-80-9) + (+)-(4S)-2-benzyl-8,9-dimethoxy-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione (340961-59-3) → (S)-2-Benzyl-6,7-dimethoxy-4-methyl-1-methylene-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 65 ℃; for 3.5h;

DOI:10.1016/S0040-4020(01)00046-1

upstream raw materials:

2-Amino-4,5-dimethoxybenzoic acid

Downstream raw materials:

(1S,4S)-2-Benzyl-1-bromo-6,7-dimethoxy-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

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