5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10

Base Information

• Chemical Name: 5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10
• CAS No.: 191211-56-0
• Molecular Formula: C₂₉H₄₂O₁₁
• Molecular Weight: 566.646
• Mol file: 191211-56-0.mol

Synonyms:5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10

Chemical Property of 5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10

There total 2 articles about 5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.115,19]octatriaconta-1(37),15,17,19(38),33,35-hexaen-17-ylmethyl ester (253170-47-7) → 5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10 (191211-56-0) + Ac-Leu-Phe-Trp-OCH3

Guidance literature:

With sodium methylate; at 20 ℃; for 0.166667h;

DOI:10.1016/S0040-4039(99)01507-5

Reference yield:

methanol (67-56-1) + (S)-2-{(S)-2-[(S)-2-Acetylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.115,19]octatriaconta-1(37),15,17,19(38),33,35-hexaen-17-ylmethyl ester (253170-51-3) → 5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10 (191211-56-0) + Ac-Trp-Phe-Phe-CO2Me

Guidance literature:

With sodium methylate; at 20 ℃; for 0.166667h;

DOI:10.1016/S0040-4039(99)01507-5

Reference yield: 75.0%

5-hydroxymethylene-1,3-phenylene-1',3'-phenylene-32-crown-10 (191211-56-0) + 1-(4'-chloromethylphenyl)-1-(2'',2'',6'',6''-tetra-methyl-1-piperidinyloxy)ethyl (212132-38-2) → 1-{1-[4-(2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.115,19]octatriaconta-1(37),15,17,19(38),33,35-hexaen-17-ylmethoxymethyl)-phenyl]-ethoxy}-2,2,6,6-tetramethyl-piperidine

Guidance literature:

With sodium hydride; In tetrahydrofuran; Heating;

DOI:10.1021/ma047811y

upstream raw materials:

methanol

(S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

(S)-2-{(S)-2-[(S)-2-Acetylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

Downstream raw materials:

4-fluoro-3-nitro-benzoic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1(37),15,17,19(38),33,35-hexaen-17-ylmethyl ester

2-benzoylamino-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester