11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Base Information

• Chemical Name: 11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline
• CAS No.: 1454697-59-6
• Molecular Formula: C₂₁H₁₈F₃N
• Molecular Weight: 341.376
• Mol file: 1454697-59-6.mol

Synonyms:11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Chemical Property of 11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

There total 5 articles about 11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(4-trifluoromethylphenyl)(phenyl)iodonium triflate (1011502-15-0) + (8-azidooct-1-yn-1-yl)benzene → 11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline (1454697-59-6)

Guidance literature:

With copper(l) iodide; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1055/s-0034-1379248

Reference yield: 48.0%

bis(4-(trifluoromethyl)phenyl)iodonium trifluoromethanesulfonate (871362-15-1) + 8-phenyloct-7-ynenitrile (1454697-96-1) → 11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline (1454697-59-6)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 130 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol402164s

Reference yield:

phenylacetylene (536-74-3) → 11-phenyl-2-(trifluoromethyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline (1454697-59-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: sodium azide / dimethyl sulfoxide / 36 h / 20 °C

3.1: copper(l) iodide / 1,2-dichloro-ethane / 24 h / 60 °C / Sealed tube; Inert atmosphere

With copper(l) iodide; n-butyllithium; sodium azide; In tetrahydrofuran; hexane; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1055/s-0034-1379248

upstream raw materials:

bis(4-(trifluoromethyl)phenyl)iodonium trifluoromethanesulfonate

8-phenyloct-7-ynenitrile

phenylacetylene

1 ,6-dibromohexane