2,2-difluoro-2-phenylacetophenone

Base Information

• Chemical Name: 2,2-difluoro-2-phenylacetophenone
• CAS No.: 365-01-5
• Molecular Formula: C₁₄H₁₀F₂O
• Molecular Weight: 232.23
• Mol file: 365-01-5.mol

Synonyms:2,2-difluoro-2-phenylacetophenone

Chemical Property of 2,2-difluoro-2-phenylacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-difluoro-2-phenylacetophenone

There total 55 articles about 2,2-difluoro-2-phenylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(Z)-2,2'-[1,2-(biphenyl)eth-1-ene-1,2-diyl]bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (151416-94-3) → 2,2-difluoro-2-phenylacetophenone (365-01-5)

Guidance literature:

(Z)-2,2'-[1,2-(biphenyl)eth-1-ene-1,2-diyl]bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane); With sodium hydroxide; Selectfluor; In acetonitrile; at 25 ℃; for 15h;

With sodium hydroxide; In acetonitrile;

DOI:10.1055/s-2005-865354

Reference yield: 93.0%

bromobenzene (108-86-1,52753-63-6) + 2,2-difluoro-1-phenylethanone (395-01-7) → 2,2-difluoro-2-phenylacetophenone (365-01-5)

Guidance literature:

With C₂₈H₄₁ClNPPd; caesium carbonate; In toluene; at 100 ℃; for 24h; Reagent/catalyst; Sealed tube;

DOI:10.1021/ja501117v

Reference yield: 93.0%

α-bromo-α,α-difluoro-acetophenone (1610-04-4) + phenylboronic acid (98-80-6) → 2,2-difluoro-2-phenylacetophenone (365-01-5)

Guidance literature:

With [2,2]bipyridinyl; nickel(II) nitrate hexahydrate; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201405653

upstream raw materials:

2,2-difluoro-1,2-diphenylethan-1-ol

diphenyl acetylene

benzil monohydrazone

methanol

Downstream raw materials:

benzil

2,2-difluoro-1,2-diphenylethan-1-ol

2-methyl-4,5-diphenyloxazole

2-fluoro-1,2-diphenylethanone