3,5-difluorophenyl selenocyanate

Base Information

• Chemical Name: 3,5-difluorophenyl selenocyanate
• CAS No.: 183137-78-2
• Molecular Formula: C₇H₃F₂NSe
• Molecular Weight: 218.064
• Mol file: 183137-78-2.mol

Synonyms:3,5-difluorophenyl selenocyanate

Chemical Property of 3,5-difluorophenyl selenocyanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3,5-difluorophenyl selenocyanate

There total 1 articles about 3,5-difluorophenyl selenocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-difluoroaniline (372-39-4) + potassium selenocyanate (3425-46-5) → 3,5-difluorophenyl selenocyanate (183137-78-2)

Guidance literature:

With hydrogenchloride; sodium acetate; sodium nitrite; Yield given. Multistep reaction; 1.) 0 deg C, 1 h, 2.) H₂O, 1 h, RT;

DOI:10.1002/jhet.5570330446

Reference yield: 80.0%

3,5-difluorophenyl selenocyanate (183137-78-2) → bis(3,5-difluorophenyl) diselenide (172256-63-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 3h; Ambient temperature;

DOI:10.1002/jhet.5570330446

Reference yield:

3,5-difluorophenyl selenocyanate (183137-78-2) → 6-[(3,5-difluorophenyl)selenenyl]-1-(ethoxymethyl)-5-isopropyl-2-thiouracil (172255-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / aq. NaOH / ethanol / 3 h / Ambient temperature

2: 1.) LDA / 1.) THF, cyclohexane, 1 h, 2.) THF, cyclohexane, -70 deg C, 1 h

With sodium hydroxide; lithium diisopropyl amide; In ethanol;

DOI:10.1002/jhet.5570330446

upstream raw materials:

3,5-difluoroaniline

potassium selenocyanate

Downstream raw materials:

bis(3,5-difluorophenyl) diselenide

6-[(3,5-difluorophenyl)selenenyl]-1-(ethoxymethyl)-5-isopropyl-2-thiouracil

6-[(3,5-difluorophenyl)selenenyl]-1-(ethoxymethyl)-5-isopropyluracil

Refernces