4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate

Base Information

• Chemical Name: 4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate
• CAS No.: 535937-59-8
• Molecular Formula: C₁₆H₁₂F₃NO₅S
• Molecular Weight: 387.336
• Mol file: 535937-59-8.mol

Synonyms:4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate

Chemical Property of 4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate

There total 2 articles about 4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-Nitrophenyl chloroformate (7693-46-1) + 2-(4-trifluoromethyl-phenylsulfanyl)-ethanol (535937-56-5) → 4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate (535937-59-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4039(03)00010-8

Reference yield:

4-chlorobenzotrifluoride (98-56-6) → 4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate (535937-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / K₂CO₃ / dimethylformamide / Heating

2: 86 percent / pyridine / CH₂Cl₂ / 20 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(03)00010-8

Reference yield: 77.4%

ethyl 1-methyl-4-nitroimidazole-2-carboxylate (109012-23-9) + 4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate (535937-59-8) → 1-methyl-4-[2-(4-trifluoromethyl-phenylsulfanyl)ethoxycarbonylamino]-1H-imidazole-2-carboxylic Acid Ethyl Ester (535937-76-9)

Guidance literature:

With dmap; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In palladium-carbon; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

upstream raw materials:

4-Nitrophenyl chloroformate

2-(4-trifluoromethyl-phenylsulfanyl)-ethanol

4-chlorobenzotrifluoride

Downstream raw materials:

1-methyl-4-[2-(4-trifluoromethyl-phenylsulfanyl)ethoxycarbonylamino]-1H-imidazole-2-carboxylic Acid Ethyl Ester

1-methyl-4-[2-(4-trifluoromethyl-phenylsulfanyl)ethoxycarbonylamino]-1H-pyrrole-2-carboxylic acid methyl ester

1-methyl-4-[2-(4-trifluoromethyl-phenylsulfanyl)-ethoxy carbonylamino]-1H-pyrrole-2-carboxylic acid

1-methyl-4-[2-(4-trifluoromethyl-phenylsulfanyl)-ethoxycarbonylamino]-1H-imidazole-2-carboxylic acid