N-(N^α-tert-butoxycarbonyl-N^ε-carbobenzoxy-L-lysyl)glycine ethyl ester

Base Information

• Chemical Name: N-(N^α-tert-butoxycarbonyl-N^ε-carbobenzoxy-L-lysyl)glycine ethyl ester
• CAS No.: 33043-26-4
• Molecular Formula: C₂₃H₃₅N₃O₇
• Molecular Weight: 465.547
• Mol file: 33043-26-4.mol

Synonyms:N-(N^α-tert-butoxycarbonyl-N^ε-carbobenzoxy-L-lysyl)glycine ethyl ester

Chemical Property of N-(N^α-tert-butoxycarbonyl-N^ε-carbobenzoxy-L-lysyl)glycine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N^α-tert-butoxycarbonyl-N^ε-carbobenzoxy-L-lysyl)glycine ethyl ester

There total 5 articles about N-(N^α-tert-butoxycarbonyl-N^ε-carbobenzoxy-L-lysyl)glycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Boc-Lys(Z)-OH (2389-45-9) + glycine ethyl ester hydrochloride (623-33-6) → N-(Nα-tert-butoxycarbonyl-Nε-carbobenzoxy-L-lysyl)glycine ethyl ester (33043-26-4)

Guidance literature:

With 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

DOI:10.1021/acs.jmedchem.9b00255

Reference yield:

Boc-Lys(Z)-OSu (34404-36-9) + glycine ethyl ester hydrochloride (623-33-6) → N-(Nα-tert-butoxycarbonyl-Nε-carbobenzoxy-L-lysyl)glycine ethyl ester (33043-26-4)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1002/hlca.19720550403

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + C39H45N7O9 → N-(Nα-tert-butoxycarbonyl-Nε-carbobenzoxy-L-lysyl)glycine ethyl ester (33043-26-4)

Guidance literature:

With triethylamine; In ethyl acetate;

upstream raw materials:

Boc-Lys(Z)-OSu

glycine ethyl ester hydrochloride

Boc-Lys(Z)-OH

GlyOEt*HCl

Downstream raw materials:

N-(N^α-tert-butoxycarbonyl-N^ε-carbobenzoxy-L-lysyl)glycine

H-L-Lys(Z)-Gly-OEt*HCl

N-(N^ε-carbobenzoxy-L-lysyl)-glycine

N-α-(1-carboxy-3-phenylpropyl)-N^ε-benzyloxycarbonyl-L-lysyl>glycine