4'-Chloro-2,2,2'-trimethylpropionanilide

Base Information

Chemical Name:4'-Chloro-2,2,2'-trimethylpropionanilide
CAS No.:68965-77-5
Molecular Formula:C₁₂H₁₆ClNO
Molecular Weight:225.718
Hs Code.:
European Community (EC) Number:659-318-9
Nikkaji Number:J1.185.976C

Synonyms:SCHEMBL18088737;AKOS002957934;N-(2-Methyl-4-chlorophenyl)pivalamide;4'-CHLORO-2,2,2'-TRIMETHYLPROPIONANILIDE

Suppliers and Price of 4'-Chloro-2,2,2'-trimethylpropionanilide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4'-Chloro-2,2,2'-trimethylpropionanilide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:225.0920418
Heavy Atom Count:15
Complexity:234

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)Cl)NC(=O)C(C)(C)C

Technology Process of 4'-Chloro-2,2,2'-trimethylpropionanilide

There total 5 articles about 4'-Chloro-2,2,2'-trimethylpropionanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 61495-04-3
2,2-dimethyl-N-(2-methylphenyl)propanamide

: 68965-77-5
N-(4-chloro-2-methylphenyl)pivalamide

Guidance literature:: With hydrogenchloride; [bis(acetoxy)iodo]benzene; In water; 1,2-dichloro-ethane; at 50 ℃; for 4h; Reagent/catalyst; regioselective reaction;
DOI:10.1016/j.chempr.2018.11.007

Reference yield:

: 3282-30-2
pivaloyl chloride

: 95-69-2
4-chloro-2-methylbenzeneamine

: 68965-77-5
N-(4-chloro-2-methylphenyl)pivalamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/jm00401a024

Reference yield:

: 3282-30-2
pivaloyl chloride

: 68965-77-5
N-(4-chloro-2-methylphenyl)pivalamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: hydrogenchloride; [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane; water / 4 h / 50 °C

With hydrogenchloride; [bis(acetoxy)iodo]benzene; triethylamine; In dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.chempr.2018.11.007