5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide

Base Information

Chemical Name:5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide
CAS No.:1352200-28-2
Molecular Formula:C₁₆H₁₉N₃O₃S
Molecular Weight:333.411
Hs Code.:

Synonyms:5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide

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Chemical Property of 5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide

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Technology Process of 5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide

There total 4 articles about 5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1270034-30-4
5-(tert-butoxycarbonylamino)-2-phenylthiazole-4-carboxylic acid

: 74-89-5
methylamine

: 1352200-28-2
5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide

Guidance literature:: With 4-methyl-morpholine; HATU; In tetrahydrofuran; at 75 ℃; for 6h;

Reference yield:

: 31785-06-5
5-amino-2-phenylthiazole-4-carboxylic acid ethyl ester

: 1352200-28-2
5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / dichloromethane / 2 h / 20 °C

2: lithium hydroxide / ethanol; water; tetrahydrofuran / 0 - 50 °C

3: 4-methyl-morpholine; HATU / tetrahydrofuran / 6 h / 75 °C

With 4-methyl-morpholine; dmap; HATU; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 55828-02-9
2-benzoylamino-2-cyanoacetic acid ethyl ester

: 1352200-28-2
5-tert-butoxycarbonylamino-2-phenyl-thiazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / toluene / 120 h / 100 °C / Inert atmosphere

2: dmap / dichloromethane / 2 h / 20 °C

3: lithium hydroxide / ethanol; water; tetrahydrofuran / 0 - 50 °C

4: 4-methyl-morpholine; HATU / tetrahydrofuran / 6 h / 75 °C

With Lawessons reagent; 4-methyl-morpholine; dmap; HATU; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;