3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid

Base Information

Chemical Name:3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid
CAS No.:1360598-35-1
Molecular Formula:C₂₄H₂₇N₃O₆S
Molecular Weight:485.561
Hs Code.:

Synonyms:3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid

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Chemical Property of 3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid

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Technology Process of 3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid

There total 8 articles about 3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1360598-33-9
ethyl 3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylate

: 1360598-35-1
3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid

Guidance literature:: With water; potassium hydroxide; In methanol; at 50 ℃; for 8h;

Reference yield:

: 4377-33-7
2-chloromethylpyridine

: 1360598-35-1
3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate; cesium fluoride / N,N-dimethyl-formamide / 20 - 60 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C

3.1: tetrahydrofuran / 18 h / Reflux

3.2: 24 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4.2: 13 h / -5 - 20 °C

5.1: potassium carbonate; potassium iodide / butan-1-ol / 72 h / Reflux

6.1: triethylamine / dichloromethane / 3 h

7.1: potassium hydroxide; water / methanol / 8 h / 50 °C

With water; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; cesium fluoride; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1360598-30-6
ethyl 3-amino-1-(phenylsulfonyl)indolizine-2-carboxylate

: 1360598-35-1
3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / butan-1-ol / 72 h / Reflux

2: triethylamine / dichloromethane / 3 h

3: potassium hydroxide; water / methanol / 8 h / 50 °C

With water; potassium carbonate; triethylamine; potassium iodide; potassium hydroxide; In methanol; dichloromethane; butan-1-ol;