C₁₂H₂₁F

Base Information

• Chemical Name: C₁₂H₂₁F
• CAS No.: 1415315-15-9
• Molecular Formula: C₁₂H₂₁F
• Molecular Weight: 184.297
• Mol file: 1415315-15-9.mol

Synonyms:C₁₂H₂₁F

Chemical Property of C₁₂H₂₁F

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₂H₂₁F

There total 5 articles about C₁₂H₂₁F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylmagnesium bromide (931-50-0) → C12H21F (1415315-15-9) + C12H21F

Guidance literature:

Multi-step reaction with 5 steps

1.1: diethyl ether / 2 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

3.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -78 - 0 °C

4.1: triphenylphosphine; carbon tetrabromide / acetonitrile / 1 h / 0 - 20 °C

5.1: C₃₇H₃₅N₂O⁽¹⁺⁾*Cl^(1-) / diethyl ether / -15 °C / Inert atmosphere

With carbon tetrabromide; C₃₇H₃₅N₂O⁽¹⁺⁾*Cl^(1-); sodium hydride; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; toluene; acetonitrile;

DOI:10.1039/c2cc36513h

Reference yield:

C10H16BrF + ethylmagnesium bromide (925-90-6) → C12H21F (1415315-15-9) + C12H21F

Guidance literature:

With C₃₇H₃₅N₂O⁽¹⁺⁾*Cl^(1-); In diethyl ether; at -15 ℃; Overall yield = 60 %; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc36513h

Reference yield:

1-cyclohexyl-2-fluoroethan-1-one (768-04-7) → C12H21F (1415315-15-9) + C12H21F

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C

1.2: 0 - 20 °C

2.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -78 - 0 °C

3.1: triphenylphosphine; carbon tetrabromide / acetonitrile / 1 h / 0 - 20 °C

4.1: C₃₇H₃₅N₂O⁽¹⁺⁾*Cl^(1-) / diethyl ether / -15 °C / Inert atmosphere

With carbon tetrabromide; C₃₇H₃₅N₂O⁽¹⁺⁾*Cl^(1-); sodium hydride; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; toluene; acetonitrile;

DOI:10.1039/c2cc36513h

upstream raw materials:

1-cyclohexyl-2-fluoroethan-1-one

C₁₂H₁₉FO₂

C₁₀H₁₇FO

ethylmagnesium bromide