(1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid

Base Information

• Chemical Name: (1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid
• CAS No.: 120697-91-8
• Molecular Formula: C₁₈H₂₆O₄
• Molecular Weight: 306.402
• Mol file: 120697-91-8.mol

Synonyms:(1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid

Chemical Property of (1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid

There total 3 articles about (1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Methyl (1S,3R)-1-benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylate (120697-90-7) → (1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid (120697-91-8)

Guidance literature:

With sodium hydroxide; In methanol; at 130 ℃; for 20h;

DOI:10.1055/s-1988-27769

Reference yield:

benzyl bromide (100-39-0) → (1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid (120697-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KH / 1.) THF, 0 deg C, 2.) 0 deg C, 22 h

2: 91 percent / 1N aq. NaOH / methanol / 20 h / 130 °C

With sodium hydroxide; potassium hydride; In methanol;

DOI:10.1055/s-1988-27769

Reference yield:

Methyl (1S,3R)-1-hydroxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylate (120697-89-4) → (1S,3R)-1-Benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylic acid (120697-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KH / 1.) THF, 0 deg C, 2.) 0 deg C, 22 h

2: 91 percent / 1N aq. NaOH / methanol / 20 h / 130 °C

With sodium hydroxide; potassium hydride; In methanol;

DOI:10.1055/s-1988-27769

upstream raw materials:

Methyl (1S,3R)-1-benzyloxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylate

benzyl bromide

Methyl (1S,3R)-1-hydroxy-3-methoxymethyl-2,2,3-trimethylcyclopentanecarboxylate