(6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid

Base Information

Chemical Name:(6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid
CAS No.:1329169-70-1
Molecular Formula:C₂₉H₄₇N₅O₇Si
Molecular Weight:605.807
Hs Code.:

(6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid

Synonyms:(6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid

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Chemical Property of (6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid

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Technology Process of (6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid

There total 10 articles about (6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1329169-69-8
(6S)-6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhexanoic acid

: 1329169-70-1
(6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 60 ℃; for 1h;

Reference yield:

: 1329169-67-6
methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-((trifluoroacetyl)amino)phenyl)carbamate

: 1329169-70-1
(6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 1.17 h / 40 °C / Inert atmosphere

1.2: 40 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / methanol / 5 h / 60 °C

3.2: pH 6

With water; hydrogen; toluene-4-sulfonic acid; lithium hydroxide; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 1329167-30-7
tert-butyl N-[(1S)-1-(4-{2-amino-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

: 1329169-70-1
(6S)-6-(4-(2-amino-4-((methoxycarbonyl)amino)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethyl acetate / 1 h / 0 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane / 1.17 h / 40 °C / Inert atmosphere

2.2: 40 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / Inert atmosphere

4.1: water; lithium hydroxide / methanol / 5 h / 60 °C

4.2: pH 6

With water; hydrogen; toluene-4-sulfonic acid; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate;