(1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone

Base Information

• Chemical Name: (1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone
• CAS No.: 1228255-36-4
• Molecular Formula: C₂₁H₁₇N₃O₃
• Molecular Weight: 359.384
• Mol file: 1228255-36-4.mol

Synonyms:(1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone

Chemical Property of (1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone

There total 2 articles about (1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(benzyloxy)-3-methoxybenzoic acid (1486-53-9) + 1-(methanesulfonyl)-1H-1,2,3-benzotriazole (37073-15-7) → (1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone (1228255-36-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1219383

Reference yield: 66.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + 3-methoxy-4-hydroxybenzoic acid (121-34-6) + benzyl bromide (100-39-0) → (1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone (1228255-36-4)

Guidance literature:

3-methoxy-4-hydroxybenzoic acid; With thionyl chloride; In methanol;

benzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide;

1,2,3-Benzotriazole; Further stages;

DOI:10.1016/j.tetlet.2018.03.064

Reference yield: 91.0%

(1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone (1228255-36-4) + 2-hydroxy-3,4,5,6-tetramethoxyacetophenone (3162-28-5) → C27H28O9 (29201-96-5)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -30 - 0 ℃;

DOI:10.1016/j.tetlet.2018.03.064

upstream raw materials:

4-(benzyloxy)-3-methoxybenzoic acid

1-(methanesulfonyl)-1H-1,2,3-benzotriazole

1,2,3-Benzotriazole

3-methoxy-4-hydroxybenzoic acid

Downstream raw materials:

3′-methoxy-4′-hydroxy-5,6,7,8-tetramethoxyflavone

4'-benzyloxy-3',5,6,7,8-pentamethoxyflavone

8-methoxycirsilineol

C₂₇H₂₈O₉